Acta Pharmaceutica Sinica B2026
Engineered cyclic peptide targeting ITGA5 disrupts tumor-stroma interaction to overcome desmoplasia and resistance in pancreatic ductal adenocarcinoma
Prakash J, Metselaar JM, et al.
An engineered cyclic peptide (cyAV3.3) targeting integrin α5 disrupts CAF-driven desmoplasia and tumor–stroma crosstalk, reducing resistance and stemness markers, decompressing tumor vasculature, and potentiating gemcitabine efficacy in xenograft and KPC PDAC models.
OncologyIntegrinsPeptide therapeuticsFibrosis
Read publication→Science Advances2019
ITGA5 inhibition in pancreatic stellate cells attenuates desmoplasia and potentiates efficacy of chemotherapy in pancreatic cancer
Kuninty PR, Bansal R, De Geus SWL, Mardhian DF, Schnittert J, van Baarlen J, Storm G, Bijlsma MF, van Laarhoven HW, Metselaar JM, Kuppen PJK, Vahrmeijer AL, Ostman A, Sier CFM, Prakash J.
Selective inhibition of integrin α5 (ITGA5) on pancreatic stellate cells reduces desmoplasia and restores the efficacy of chemotherapy in preclinical models of pancreatic ductal adenocarcinoma.
OncologyIntegrinsFibrosis
Read publication→Trends in Cancer2019
Targeting pancreatic stellate cells in cancer
Schnittert J, Bansal R, Prakash J.
A review of therapeutic strategies targeting activated pancreatic stellate cells to remodel the tumor stroma and improve treatment outcomes in pancreatic cancer.
OncologyFibrosis
Read publication→FASEB Journal2019
Integrin α11 in pancreatic stellate cells regulates tumor stroma interaction in pancreatic cancer
Schnittert J, Bansal R, van Baarlen J, Ostman A, Prakash J.
Integrin α11 on pancreatic stellate cells mediates tumor–stroma crosstalk, supporting its role as a therapeutic target in the desmoplastic microenvironment of pancreatic cancer.
OncologyIntegrinsFibrosis
Read publication→Experimental & Molecular Medicine2017
Integrin alpha 11 in the regulation of the myofibroblast phenotype: implications for fibrotic diseases
Bansal R, Nakagawa S, Yazdani S, van Baarlen J, Venkatesh A, Koh AP, Song W, Goossens N, Watanabe H, Beasley MB, Powell CA, Storm G, Kaminski N, van Goor H, Friedman SL, Hoshida Y, Prakash J.
Integrin α11 is identified as a key regulator of the myofibroblast phenotype across fibrotic tissues, supporting its therapeutic relevance in liver, lung, and other fibrotic diseases.
FibrosisIntegrins
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